《男子高中生的日常》以真田北男校为舞台，围绕着主角忠邦（入野自由配音），以及他的死党秀则（杉田智和配音）和吉竹（铃村健一配音）的日常高中生活而展开。忠邦主要担任吐槽的角色，长相中性的他常常被秀则和吉竹联合欺负。登场人物还有同校学生会的元治、唐泽、副会长和会长等人，这是一群基本上没有女朋友的男校学生，在鲜有女生参与的情况下，展开了插科打诨的日常高中生活。
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